Abstract
To investigate in vivo confocal microscopy (IVCM) findings in patients with Posner-Schlossman Syndrome (PSS), we compared the IVCM findings from the eyes of patients with: PSS (44 eyes); herpes simplex keratitis (HSK) (45 eyes); HLA-B27 anterior uveitis (B27AU) (45 eyes); and with acute attack of primary angle closure (aPAC) (43 eyes). The central Langerhans cells (LCs) grade at the level of corneal basal epithelial cells of the PSS group (2.33 ± 0.55) was similar to that of the HSK group (2.63 ± 0.67) (χ2 = −1.435, P = 0.174) but was significantly higher than those of the B27AU group (1.80 ± 0.79) (χ2 = 2.311, P = 0.023) and the aPAC group (1.75 ± 0.46) (χ2 = 2.701, P = 0.022). The keratocyte activation grade of the PSS group (1.55 ± 0.76) was similar to that of the HSK group (1.65 ± 0.81) (χ2 = 1.104, P = 0.675) but was significantly higher than those of the B27AU group (1.00 ± 0.71) (χ2 = 2.364, P = 0.025) and aPAC group (1.75 ± 0.46) (χ2 = 2.532, P = 0.027). The LCs and keratocyte activation grades observed by IVCM in patients with PSS were higher than those in patients with B27AU and with aPAC, but they were similar to those in patients with HSK. This implies that PSS might be related to viral infection.
Highlights
Glaucomatocyclitis crisis, known as Posner-Schlossman Syndrome (PSS), is an uncommon form of cyclitis with recurrent intraocular pressure (IOP) elevation[1]
The purpose of this study is to identify the corneal morphology of PSS patients by In vivo confocal microscopy (IVCM) and compare it with the corneal morphologies of patients with herpes simplex keratitis (HSK), HLA-B27 anterior uveitis (B27AU) and attack of primary angle closure (aPAC)
Forty-five patients with HSK, 47 with B27AU and 43 with aPAC were enrolled in the control groups at the same time
Summary
Glaucomatocyclitis crisis, known as Posner-Schlossman Syndrome (PSS), is an uncommon form of cyclitis with recurrent intraocular pressure (IOP) elevation[1]. It is identified as a unilateral condition of recurrent mild cyclitis with a few keratic precipitates (KP). IVCM allows for in vivo examination of the human cornea at all cellular levels by continuous confocal scanning[13]. It is widely used in the diagnosis of corneal diseases, such as viral keratitis, keratoconus and corneal dystrophy[14,15,16,17,18]. The purpose of this study is to identify the corneal morphology of PSS patients by IVCM and compare it with the corneal morphologies of patients with herpes simplex keratitis (HSK), HLA-B27 anterior uveitis (B27AU) and aPAC
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