In Vivo Confocal Microscopy of Corneal in Posner-Schlossman Syndrome

Abstract

Objective: To investigate the in vivo confocal microscopy (IVCM) findings of corneal in Posner-Schlossman syndrome (PSS) patients. Methods: In this retrospective study, the record of 56 PSS patients (56 eyes) who visited Peking University Third Hospital Ophthalmology Department from May 2014 to May 2017 were reviewed. Data of visual acuity, intraocular pressure (IOP), keratic precipitate (KP) and IVCM results were recorded. IVCM examination included corneal stromal cell activation, corneal endothelium cell change, the morphology of KPs and the morphology of Langerhans cells (LCs). Statistical analysis was performed by a chi-square test. Results: Visual acuity of the 56 PSS patients was 0.3±0.2 (LogMAR), and IOP was 29.7±13.4 mmHg with 2.6±1.0 anti-glaucoma medications. IVCM identified 50 patients (89%) who had keratocyte activation of the affected eyes. LCs could be seen in 32 patients (57%) of the affected eyes and 6 types of KP could be observed in 44 patients (79%) of the affected eyes. There was a statistically significant difference with contralateral eyes (χ2=69.14, 41.29, 60.89, P<0.001). The corneal endothelial cells of all patients were hexagon. Conclusions: Keratocyte activation, LCs in the endothelium layer and different types of KP could be seen in PSS patients. Key words: Posner-Schlossman syndrome; in vivo confocal microscopy; keratic precipitate; Langerhans cells