Abstract
The cell mediated immune response to Mycobacterium tuberculosis and Mycobacterium salmoniphilum was studied in rainbow trout ( Salmo gairdneri) by delayed hypersensitivity skin reactions, thymus imprint analysis and a modified skin window assay. Test fish immunized with complete Freund's adjuvant containing M. tuberculosis were compared to control fish which received either incomplete Freund's adjuvant or phosphate buffered saline. Skin testing produced typical delayed hypersensitivity reactions with a significant difference between the test and control fish. Cross reactivity was produced when sensitized fish were tested with M. salmoniphilum. Imprints of thymus tissue from sensitized trout showed a significant shift in cell populations. Skin window studies supported the presence of cell mediated immunity by demonstrating the presence of activated macrophages at the dermal layer.
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