Abstract
Most of previous works studied the bioactivity of tertiary soda-lime-borate as in vitro method, but, there have been no previous studies investigated the in vivo compatibility of such glass. This work was mainly aimed at in vivo assessment of bone formation of tertiary soda-lime-borate bioactive glass doped with Sr. the glass composition was based on 60 B2O3–20 Na2O–(20-x) CaO–xSrO (wt%), where, x = 0 and 10 wt% (samples encoded B0 and BS, respectively). The in vivo test was conducted in femoral bone defect of Sprague-Dawley adult male rats after 3 and 6 weeks post-surgery using the histological analyses and bone formation markers (alkaline phosphatase (ALP) and osteocalcin (OCN)). Moreover, the possible systemic toxicity was studied using different biochemical analyses (alanine transaminase, aspartate transaminase, urea and creatinine). The result of bone markers showed that serum OCN level increased in rat implanted with sample B0 than that observed in sample BS at 3 and 6 weeks post-implantation, while this finding was reversed in ALP activity. In vivo bioactivity test showed that implantation of all borate glasses did not demonstrate local or general complications in all rats, and they exhibited nearly complete bone mineralization. However, BS glass was formed more new bone % than B0 one in long implantation time. In conclusion, the synthesized bioactive borate glasses were safe materials, and introducing of Sr in the glass was enhanced formation of new bone throughout long time of implantation. Accordingly, this glass can be used as a potential substitute for bone regenerative materials and a hosting for strontium ions delivery.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Journal of Inorganic and Organometallic Polymers and Materials
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.