Abstract
The aim of the present study was to evaluate the response of surrounding tissues to newly developed poly(trimethylene carbonate) (PTMC) membranes. Furthermore, the tissue formation beneath and the space maintaining properties of the PTMC membrane were evaluated. Results were compared with a collagen membrane (Geistlich BioGide), which served as control. Single-sided standardized 5.0 mm circular bicortical defects were created in the mandibular angle of rats. Defects were covered with either the PTMC membrane or a collagen membrane. After 2, 4 and 12 weeks rats were sacrificed and histology was performed. The PTMC membranes induced a mild tissue reaction corresponding to a normal foreign body reaction. The PTMC membranes showed minimal cellular capsule formation and showed signs of a surface erosion process. Bone tissue formed beneath the PTMC membranes comparable to that beneath the collagen membranes. The space maintaining properties of the PTMC membranes were superior to those of the collagen membrane. Newly developed PTMC membranes can be used with success as barrier membranes in critical size rat mandibular defects.
Highlights
Guided bone regeneration (GBR) is a widely used modality for restoring bone deficiencies
Defects and the poly(trimethylene carbonate) (PTMC) and collagen barrier membranes could be identified after 2–4 weeks (Figs. 1, 2)
The PTMC membrane appeared white in the sections, the collagen barrier membrane appeared similar to connective tissue, it could be differentiated from host connective tissue
Summary
Guided bone regeneration (GBR) is a widely used modality for restoring bone deficiencies. In GBR the use of barrier membranes leads to predictable bone formation, by preventing in-growth of fibroblasts and provision of space for osteogenesis within a blood clot formed in the defect [1]. A variety of biocompatible membranes have been used to achieve this desired barrier effect. The optimal barrier membrane should exert biocompatible, synthetic, degradable and space maintaining properties [2, 3]. Non-resorbable membranes have better space maintaining properties compared to resorbable membranes. A major disadvantage of non-resorbable membranes is the need for their removal in a second operation
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