Abstract
A microdialysis probe was implanted into the striatum of young (4- to 5-month-old) and aged (26- to 27-month-old) Fischer 344 male rats to assess age-related alterations in striatal dopamine (DA) release. Basal levels of DA and the magnitude of DA response evoked by 50 mM and 100 mM high potassium (K +) in aged rats were similar to those in young rats. Furthermore, K +-evoked DA release did not correlate with motor performance within either age group. In contrast, amphetamine (250 μM) evoked-DA release of aged rats was significantly lower than that of young rats. Moreover, the enhancement of K +-evoked DA release by oxotremorine (500 μM) was significantly attenuated in aged rats. These results indicate that a putative DA release mechanism and its cholinergic modulation of the aged striatum are impaired.
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