In vivo assessment of pharmacological potentials of different fractions of Fagonia olivieri DC

Abstract

Introduction: Hemostasis mechanism involves blood coagulation as one of the step which is responsible for blood clot formation that restricts blood flow at site of injury. By inhibiting coagulation cascade and reducing thrombus formation, several cardiovascular diseases (CVD) and atherosclerosis can be prevented. Traditionally, Fagonia olivieri (zygophyllaceae) is reported in the treatment of diabetes, coughs, blood purifier, cooling agent, blood vascular diseases, digestive system disorders and cancer in initial stages. Objectives: Different fractions of F. olivieri methanolic extract were evaluated in this study for their anticoagulatory, anti-inflammatory and antidepressant potentials. Methodology: Anticoagulatory, anti-inflammatory and antidepressant potentials of ethyl acetate, butanol and aqueous extracts of F. olivieri were assessed using capillary tube experiment, carrageenan induced paw edema test and forced swim test respectively. Results: The results of this investigation have revealed that ethyl acetate and butanol fractions possess significant anticoagulatory potentials as compared to control (P=0.0002). Butanol extract showed highest anti-inflammatory activity. Maximum anti-depressant activity was shown by ethyl acetate followed by n-butanol and aqueous extracts. Conclusion: Hence, it can be concluded that F. olivieri exhibits anticoagulatory, anti-inflammatory and antidepressant potentials which justifies its use for the treatment of various disorders particularly blood vascular diseases.