Abstract
Background: Mimosa pudica, a common plant of Mimosoideae family has been used as Ayurvedic herbal medicine by Bangladeshi and Chinese to treat several diseases such as hemorrhoids, hair loss, arthritis, dysentery, leprosy, jaundice, leukoderma, asthma, uterine problems. The root and bark of the plant is said to display antimicrobial activity. Hence, gargling with a decoction of the root and bark of Mimosa pudica diluted in water may help to treat toothaches. Aim of the study: The present study was designed to evaluate the presence of phytochemical groups and to investigate the neuropharmacological activity of methanol extract of Mimosa pudica (MEMP). Methodology: The neuropharmacological activity was determined by hole cross and open field test using Swiss Albino mice as experimental animal. Results: Phytochemical analysis of Mimosa pudica extract indicated the presence of tannins, alkaloids, terpenoids and flavonoids. The sample showed dose-dependent sedative activity at the doses of 200 and 400 mg/kg body weight compared to standard drug Diazepam (1 mg/kg body weight). Conclusion: MEMP showed significant sedative activity demonstrating that the extract may be useful in the development of a new sedative and anti-anxiety drug.
Highlights
According to The World Health Organization, depression is among the top ten causes of morbidity, and mortality world over [1], and it is envisaged to be the leading cause of morbidity and mortality by the year 2030 [2]
Preliminary phytochemical screening of the crude extract of Mimosa pudica revealed the presence of tannins, alkaloids, terpenoids and flavonoids
Hole Cross Test The locomotor activity lowering effect was evident for the both doses of 200 and 400 mg/kg body weight at the 2nd observation (30 min) and continued up to 3rd and 4th observation (60 and 90 min) period
Summary
According to The World Health Organization, depression is among the top ten causes of morbidity, and mortality world over [1], and it is envisaged to be the leading cause of morbidity and mortality by the year 2030 [2]. Patients with depression have symptoms that reflect a functional deficit in brain monoamine neurotransmitters, norepinephrine, serotonergic and dopaminergic systems [3]. Despite the availability of synthetic antidepressant drugs, depression remains a major medical problem [6]. A common plant of Mimosoideae family has been used as Ayurvedic herbal medicine by Bangladeshi and Chinese to treat several diseases such as hemorrhoids, hair loss, arthritis, dysentery, leprosy, jaundice, leukoderma, asthma, uterine problems. Aim of the study: The present study was designed to evaluate the presence of phytochemical groups and to investigate the neuropharmacological activity of methanol extract of Mimosa pudica (MEMP). Conclusion: MEMP showed significant sedative activity demonstrating that the extract may be useful in the development of a new sedative and anti-anxiety drug
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
