In vivo assessment of glymphatic clearance by DCE-MRI as potential prognostic biomarker of Alzheimer's disease

Abstract

Event Abstract Back to Event In vivo assessment of glymphatic clearance by DCE-MRI as potential prognostic biomarker of Alzheimer's disease Monica Van Den Berg1*, Aneta Keliris1, Inès Ben-Nejma1, Marleen Verhoye1, Georgios Keliris1 and Annemie Van Der Linden1 1 University of Antwerp, Belgium The glymphatic system (GS) is a recently identified glial-dependent brain clearance route with an implicated fundamental role in the drainage of solutes and waste proteins- such as amyloid-β and hyperphosphorylated tau (p-tau). The efficacy of the GS decreases during aging, possibly leading to an accumulation of waste proteins. This decreased glymphatic-drainage is postulated to play a key role in the initiation and progression of neurodegenerative disorders, including Alzheimer disease (AD). Therefore, understanding its function in neurodegenerative disorders is essential for the development of new diagnostic biomarkers and therapies. To investigate how GS function is altered in AD, dynamic contrast-enhanced MRI (DCE-MRI) was performed to visualize, in vivo, the ‘glymphatic flow’ in two rodent models of AD. DCE-MRI was acquired in a mouse model with inducible amyloid expression, TetO-APPSweInd, to investigate the effect of amyloid on GS function. Furthermore, DCE-MRI was performed in a translational rat model (TgF344-AD), which exhibits both amyloid and tau pathology, to assess changes in clearance due to the AD pathology. In both animal models, experiments were performed when AD pathology was already advanced. Our results demonstrate that clearance patterns are altered in both rodent models of AD. The amyloidosis mouse model displayed altered distribution patterns in the cortex, a region severely affected by amyloid plaques. In the TgF344-AD rat model, altered glymphatic clearance is observed in the thalamus, striatum, olfactory bulb and cortex, regions also affected by amyloid and tau pathology. To conclude, changes in efficacy and function of the GS are observed in rodent models of AD and these changes coincide with the presence of pathological hallmarks of AD. Future research will focus on early changes is glymphatic clearance in AD models. Acknowledgements Bio-Imaging lab, university of Antwerp Keywords: Alzheime´s Disease, glymphatic clearance, MRI, Neurodegenaration, Dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI), Glymphatic system Conference: 13th National Congress of the Belgian Society for Neuroscience , Brussels, Belgium, 24 May - 24 May, 2019. Presentation Type: Poster presentation Topic: Behavioral/Systems Neuroscience Citation: Van Den Berg M, Keliris A, Ben-Nejma I, Verhoye M, Keliris G and Van Der Linden A (2019). In vivo assessment of glymphatic clearance by DCE-MRI as potential prognostic biomarker of Alzheimer's disease. Front. Neurosci. Conference Abstract: 13th National Congress of the Belgian Society for Neuroscience . doi: 10.3389/conf.fnins.2019.96.00041 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 25 Apr 2019; Published Online: 27 Sep 2019. * Correspondence: PhD. Monica Van Den Berg, University of Antwerp, Antwerp, Belgium, monica.vandenberg@uantwerpen.be Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Monica Van Den Berg Aneta Keliris Inès Ben-Nejma Marleen Verhoye Georgios Keliris Annemie Van Der Linden Google Monica Van Den Berg Aneta Keliris Inès Ben-Nejma Marleen Verhoye Georgios Keliris Annemie Van Der Linden Google Scholar Monica Van Den Berg Aneta Keliris Inès Ben-Nejma Marleen Verhoye Georgios Keliris Annemie Van Der Linden PubMed Monica Van Den Berg Aneta Keliris Inès Ben-Nejma Marleen Verhoye Georgios Keliris Annemie Van Der Linden Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.