Abstract
AIM:To investigate in vivo antitumour activity of single-chain immunotoxin (sFv-TNF-α fusion protein). METHODS:HCC-specific killer cells were generated by transducing the recombinant retroviral virus in supernatant of the virus producing cells (C22) into human peripheral blood mononuclear cells (PBMCs). SMMC-7721 xenograft nude mice were given iv either 1×10 6 (0.2 mL) transduced or mock-transduced PBMCs once five days for three weeks and tumour growth was detected. RESULTS:Tumour growth were (20.8±4.9) mg/d in PBMCs/PST group and (28.5±6.7)mg/d in PBMCs/ pLXSN group, with a significant difference (P <0.05).
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