Abstract
Two different concentrations of D-galactose (D-gal) induced organism and skin aging in Kunming mice were used to examine comprehensively the antioxidant and antiaging activities of ethyl acetate extraction (EAE) from Idesia polycarpa defatted fruit residue for the first time. The oxygen radical absorbance capacity (ORAC) of EAE was 13.09 ± 0.11 μmol Trolox equivalents (TE)/mg, which showed EAE had great in vitro free radical scavenging and antioxidant activity. Biochemical indexes and morphological analysis of all tested tissues showed that EAE could effectively improve the total antioxidant capacity (T-AOC) of the antioxidant defense system of the aging mice, enhance the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) of tissues and serum, increase glutathione (GSH) content and decrease the malondialdehyde (MDA) content, and maintain the skin collagen, elastin, and moisture content. Meanwhile, EAE could effectively attenuate the morphological damage in brain, liver, kidney, and skin induced by D-gal and its effect was not less than that of the well-known L-ascorbic acid (VC) and α-tocopherol (VE). Overall, EAE is a potent natural antiaging agent with great antioxidant activity, which can be developed as a new medicine and cosmetic for the treatment of age-related conditions.
Highlights
One of the reasons why people will be senile gradually is the oxidative stress
With the improvement of living standards all over the world, people are increasingly concerned about their appearance and health
How to postpone skin and body aging becomes a hot topic of concern for many people
Summary
One of the reasons why people will be senile gradually is the oxidative stress. Oxidative stress is a result of imbalance between the formation of reactive oxygen species (ROS) and the in vivo antioxidant system [1, 2]. ROS contain oxygen free radicals and hydrogen peroxide [3]. Excess ROS can make the lipids of blood, cells, tissues, and so on into lipid peroxides. These peroxides can deposit on the cell membrane, which will result in the loss of function of the cell membrane and decrease in cell viability. ROS can cause cell damage, death, and exacerbate several age-related chronic diseases including cancer, Alzheimer’s disease, Parkinson’s disease, and heart disease [4]. More and more studies show that antioxidant is critical to prevent aging
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