Abstract
Cancer, which is a diverse group of diseases characterized by proliferation and spread of abnormal cells, is a major worldwide concern. Therefore, the discovery and development of new potent and selective anticancer drugs are of high importance in modern cancer research. Schiff bases containing the C=N group play a very important role in many biological activities. They have been found to possess anticancer (1,2), antimicrobial (3), antitubercular (4), antiinflammatory and anlgesic (5), antiviral (6), and pesticidal (7) properties. Not only the Schiff bases, but also Schiff base complexes with transition metals have been investigated for their anticancer activities against Ehrlich ascites carcinoma (EAC) cells in Swiss albino mice (8,9). Recently, the anticancer activities of some semicarbazones and thiosemicarbazones against EAC cells have been reported (10-12). The aim of the present study was to explore the anticancer properties of two Schiff bases, namely benzoin thiosemicarbazone (BTSC) and para-anisaldehyde semicarbazone (PAS).
Published Version
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