Abstract
The derivative of flavonoid compounds, artocarpin (1) and artonin M (2), were isolated from the root wood of Artocarpus altilis and from the root bark of A. kemando, respectively. Both plants originated from Lampung, Indonesia. The structure of the two compounds has been carefully determined by physical method and spectroscopy techniques of UV, IR, and NMR. The in vivo antimalarial test of artocarpin showed very good Plasmodium activity in female mice, with ED50 value of 34.88 mg/kg body weight (kgBW), whereas the in vitro antimalarial test of artonin M showed very strong activity with IC50 of 0.3 μg/mL (5.967 x 10-7 M).
Highlights
The antimalarial researches on flavanoid compounds isolated from artocarpus plants have been carried out and reported previously [1,2,3,4]
In this paper, we reported the in vivo antimalarial test of artocarpin isolated from A. altilis and in vitro antimalarial activity of artonin M isolated from A. kemando Miq
Compound 1 is categorized as excellent drug; it will be excellent to be developed as an antimalarial drug in the near future
Summary
The antimalarial researches on flavanoid compounds isolated from artocarpus plants have been carried out and reported previously [1,2,3,4]. Artonin E, cycloartobiloxanthone, artocarpin, cycloartocarpin isolated from A. altilis have been found to exhibit cytotoxic activity against Plasmodium falciparum All of these active compounds are prenylated on C3, and the antimalarial activity test previously performed on these compounds were usually in vitro activity test [1,2,3,4]. A. kemando Miq. is one of endemic plants that grows in Indonesia From this plant, some prenylated flavanoids have been isolated, and these include artomandin, artoindonesianin C, artonol B, and artochamin A [5]. Some prenylated flavanoids have been isolated, and these include artomandin, artoindonesianin C, artonol B, and artochamin A [5] All of these compounds have been found to show cytotoxic activity against KB cell cancer (human oral epidermoid carcinoma); this plant is known as a source of promising anticancer drug [6]. The antimalarial activity test of the compounds isolated from A. kemando is not available yet
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