Abstract
Objective:To evaluate the in vivo antiplasmodial activity of the ethanol leaf extract of Stachytarpheta cayennensis in the treatment of various ailment in Niger Delta region of Nigeria, in Plasmodium berghei infected mice.Materials and Methods:The ethanolic leaf extract of Stachytarpheta cayennensis (90-270 mg/kg/day) was screened for blood schizonticidal activity against chloroquine sensitive Plasmodium berghei berghei in mice. The schizonticidal effect during early and established infections was investigated.Result:Stachytarpheta cayennensis (90-270 mg/kg/day) exhibited significant (P< 0.05) blood schizonticidal activity both in 4-day early infection test and in established infection with a considerable mean survival time comparable to that of the standard drug, chloroquine, 5 mg/kg/day.Conclusion:The leaf extract possesses significant (P< 0.05) antiplasmodial activity which confirms it's use in folkloric medicine in the treatment of malaria.
Highlights
Two common very similar species of Stachytarpheta cayennensis grow in the tropics and are use interchangeablyin the herbal medicine systems of many countries, Stachytarpheta cayennensis and Stachytarpheta jamaicensis
Ethanolic leaf extract of Stachytarpheta cayennensis produced a dose dependent chemosuppressive effect at various doses employed in this study
The results show that Stachytarpheta cayennensis leaf is moderately toxic as shown in its LD50 value of 938.08/kg[18] and possesses a significant (P
Summary
Stachytarpheta cayennensis has been reported to be antiinflammtory, antinociceptive, anti ulcerogenic,[8,10,11]
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