In vivo Anti-inflammatory and Antidiabetic Potential of Crude Leaf Extracts of Canthium coromandelicum (Burm. f.) Alston

Abstract

The present work was carried out to evaluate anti-inflammatory and anti-diabetic activity of different crude leaf extracts of Canthium coromandelicum (Burm. f.) Alston. The crude leaf extracts of C. coromandelicum in different organic solvents like 70% acetone, 70% ethanol and 70% methanol were prepared by maceration and soxhlet method. The anti-inflammatory activity of acetone (AM), ethanol (EM) and methanol (MM) extracts obtained from maceration method was screened by carrageenan induced paw edema model in Wistar rats. Anti-diabetic activity of ethanol (ES) and methanol (MS) extracts obtained from soxhlet method was screened by alloxan induced diabetes in Wistar rats. Further, biochemical parameters and histopathology of liver, kidney and pancreas were also studied. Anti-inflammatory activity of MM and AM extract was found to be statistically significant (P < 0.05) and was shown by decrease in paw edema. EM extract also reduced paw edema but did not show significant result. Anti-diabetic activity of ES extract showed significant decrease in blood glucose level and considerable improvement in all biochemical parameters. Histopathology of liver, kidney and pancreas of rat treated with ES extract lowered the toxic effect of alloxan and cured the damaged cells of the organs.