Abstract
The objective of this study was to evaluate the antifungal activity of eucalyptus (Eucalyptus globulus) and lemongrass (Cymbopogon flexuosus) essential oils in their free and nanoemulsion forms in the murine model of vulvovaginal candidiasis (VVC). The nanoemulsions were developed by the homogenization method under high agitation and characterized according to the mean droplet size, polydispersity index, zeta potential, and pH. The murine VVC model was induced in BALB/c mice by the administration of estradiol valerate preceding the Candida albicans challenge. Nanoemulsions containing eucalyptus or lemongrass oils showed average droplet size of less than 100 nm, a polydispersity index about 0.2, negative zeta potential, and acidic pH. For in vivo treatment of VVC, the essential oils in their free form did not show antifungal activity, while the two nanoemulsions were able to reduce the fungal load similarly or better than the control animal group treated with miconazole cream. The results obtained in this study demonstrated that the use of nanoemulsions containing eucalyptus or lemongrass essential oils could be a promising alternative to be used as a proof of concept to develop a new therapy for the treatment of VVC.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
