In Vivo Antidiabetic Activity of fruit extract of Coccinia grandis Linn in Normoglycemic, Adrenaline Induced and Alloxan Induced Diabetic rat

Abstract

Diabetes mellitus (DM) is a serious global health problem and the incidence of DM is increasing in whole world in all ethnic groups, male or female for all age groups. There are various medicinal plants in India those possess antidiabetic property and traditionally used in management of diabetes. The present study aimed to evaluate antidiabetic activity of fruit extract of Coccinia grandis in normoglycemic, adrenaline induced and alloxan induced diabetic rats. Adrenaline was induced intaperitoneally at the dose of 0.8mg/kg bodyweight for induction of hyperglycaemia. Alloxan was induced intraperitoneally at the dose of 150mg/kg body weight for induction of diabetes. Blood glucose was analysed using glucose oxidase-peroxidase reactive strips. Significant antidiabetic activity was observed in ethanolic extract at the dose of 250 mg/kg in terms of reduction of fasting blood glucose level in diabetic rats. In normoglycemic rats, blood glucose was decreased significantly (P< 0.05) after 7 hr of administration of drug. In Adrenaline induced diabetic rat, blood glucose level decreased significantly (P< 0.05). In alloxan induced diabetic rats, blood glucose level decreased significantly (P< 0.05) in both acute and chronic administration for 15th day. Glipizide (1 mg/kg body wt) was taken as standard drug for the study. The result of present study shows that Coccinia grandis L. fruit extract possess significant antihyperglycemic activity and encourages the traditional use of the fruit for the treatment of diabetes mellitus.