Abstract
The present study aimed to investigate the role of several biologically active compounds from Fumaria schleicheri Soy.-Will. in anticonvulsant models. The flavonoid fraction, alkaloid fraction, individual alkaloid protopine, and polysaccharide-protein complex were isolated from the Fumaria schleicheri herb and studied along with Fumaria schleicheri dry extract in mice with pentylenetetrazole-induced seizures. According to empirical results, the expressed anticonvulsant effect of Fumaria schleicheri dry extract depends on the synergism of biologically active compounds in herbal medicine, although some individual substances (mostly protopine and the protein-polysaccharide fraction) have shown moderate anti-seizure activity.
Highlights
Epilepsy is a disorder of the brain characterised by an enduring predisposition to generate epileptic seizures and is a precursor to serious neurobiological, cognitive, psychological, and social consequences
The present research was conducted to investigate the anticonvulsant activity of the protein-polysaccharide fraction, alkaloid fraction, flavonoid fraction, and the main alkaloid of Fumaria protopine
In mice subjected to pentylenetetrazole-induced seizures [25], the Fumaria schleicheri dry extract as the reference drug sodium valproate has shown potent anticonvulsant activity, resulting in a significant increase in the latency period of the appearance of the first seizure and reducing the duration of the convulsive period in the group (Table 2)
Summary
Epilepsy is a disorder of the brain characterised by an enduring predisposition to generate epileptic seizures and is a precursor to serious neurobiological, cognitive, psychological, and social consequences. Despite the availability of a wide range of antiepileptic medicines, the development of new drugs derived from herbal remedies with anticonvulsant properties remains problematic. In the first stage of the Fumaria species anticonvulsant properties study, it was established that among other Fumariaceae family members, Fumaria schleicheri dry extract has shown a pronounced anticonvulsant activity that is probably due to differences in its chemical compositions [7]. Considering the obtained results, it was decided to analyze the role of biologically active substances or fractions from Fumaria schleicheri in anticonvulsant treatment for a deeper understanding of Fumaria schleicheri dry extract mechanisms of anti-seizure activity. This probably aided in identifying new possibilities for the pharmacological correction of epilepsy. The present research was conducted to investigate the anticonvulsant activity of the protein-polysaccharide fraction, alkaloid fraction, flavonoid fraction, and the main alkaloid of Fumaria protopine
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