Abstract
GL-T, a fraction of extract from fruiting bodies of a fungus, Ganoderma lucidum (Reishi, Ling-Zhi in China) was found to induce protective activity against Candida albicans infection in mice. Of the treatment schedules tested, intraperitoneal administration and premedication were most effective. GL-T stimulated macrophage functions such as phagocytosis and also increased delayed type hypersensitivity and antibody formation in mice. Production of interferons (IFNs) by GL-T was also confirmed, but TNF production was not detectable. The in vivo increased protective activity was abolished by treatment with carrageenan. Possible effectors which may be important in defending against the infection of C. albicans were discussed.
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