In Vivo Anticancer Activity of Cleome viscose Linn. alcoholic extract and its fractions against Ehrlich’s Ascites Carcinoma (EAC) Cell Line

Abstract

The investigation aimed to evaluate the anti-cancer properties of alcoholic extracts and the fractions Cleome viscose Linn. against Ehrlich Ascites Carcinoma (EAC) cell lines in Swiss albino mice. In the case of EAC tumor, 24 hours after tumor inoculation, the extract and fractions are administered every day within 14 days. On the fifteenth day the mice were sacrificed to monitor antitumor activity. The effect of alcoholic extracts and their fraction in terms of mean survival time, percentage increase in life span, spleen weight, ascitic fluid volume, ascitic fluid volume and angiogenesis of EAC-bearing mice and simultaneous alteration in hematological profile were estimated. Alcoholic extracts and their fractures exhibited an impact on mean survival time, percentage increase in life span, spleen weight, ascitic fluid volume, ascitic fluid volume, angiogenesis and haematological parameters in EAC tumor bearing mice. Hematological profile was reverted to normal level in the extracts and their fractions treated mice. From the current study of alcoholic extracts and its fraction of Cleome viscose Linn. exhibited antitumor action in a dose dependent manner comparable to that of standard drug. So, the current research provides a scientific basis for the curative use of Cleome viscose Linn. Which are largely attributable to the improver or synergies effect of their constituents.