Abstract
ObjectiveTo evaluate the in vivo anti-androgenic, antioxidant activity and anti-estrogenic activities of Eremomastax speciosa (E. speciosa) in order to find new method for fighting against chronic diseases such as cancer. MethodsEvaluations of antiandrogenic and antioxidant activities were carried out on male rate receiving simultaneous daily administration of testosterone and different doses of aqueous extract of E. speciosa, during a period of 10 d. The evaluation of antiestrogenic activity was carried out on mature ovariectomized female rats receiving simultaneous daily administration of estradiol and different doses of extract, for a week. Then reproductive organs were weighted, levels of prostatic acid phosphatase, superoxide dismutase and catalase as well as some hematologic parameters were measured. ResultsThe treatment significantly reduced (P<0.01) the weight of ventral prostate, penis, Cowper's gland and the level of serum prostatic acid phosphatase; while a significant decrease (P<0.01) of the catalase activity was observed. A significant increase (P<0.05) in the lymphocyte number and significant decrease of monocyte (P<0.05) were noticed. The uterine relative weight were significantly reduced (P<0.01). ConclusionsGenerally, these results denote the antiandrogenic, antiestrogenic and immunomodulatory potential of E. speciosa.
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