Abstract
The main aim of this study is to determine the anti-hyerlipidemic and anti-obesity activity of Canephora robusta in hyperlipidemia induced rats. Prepared coffee bean extract (GCE) was procured from the market which is unroasted and contains more quantity of caffeine and chlorogenic acid when compared to roasted coffee. Male albino Wister rats are fed with high fat diet (HFD) for weeks to induce hyperlipidemia in rats, which are divided into 4 groups with 4 animals in each group. Test GCBE was given in doses of 200 mg/kg and 400 mg/kg to III and IV groups which are fed with HFD for 30 days. Then blood samples were collected through retro-orbital sinus by capillaries and serum is separated for analysis. The result obtained from lipid profile which includes total cholesterol, triglycerides, very low density lipoproteins, and low density lipoproteins shows the decreased level when compared to the hyperlipidemic control. This shows the significant reduction of total body weight (p < 0.05) when given with dose of 200 mg/kg and 400 mg/kg. The present study suggests that GCBE has anti-obesity and anti-hyperlipidemic activity, where 400 mg/kg is more effective to reduce the total body weight and lipid levels when compared to 200 mg/kg. Further studies on this extract may lead to identify the possible mechanism of action and isolation of active principle from the same.
Highlights
Nowadays obesity is the most prevailing conditions in world wide
Male albino Wister rats are fed with high fat diet (HFD) for weeks to induce hyperlipidemia in rats, which are divided into 4 groups with 4 animals in each group
The result obtained from lipid profile which includes total cholesterol, triglycerides, very low density lipoproteins, and low density lipoproteins shows the decreased level when compared to the hyperlipidemic control
Summary
Obesity is a disorder involving in excessive accumulation of body fat It increases risk of diseases and health problems such as heart disease, diabetes, high blood pressure [1]. According to WHO overweight and obesity are defined as the abnormal fat accumulation that causes the risk to health [2]. Lifestyle changes such as exercise and eating healthy diet are the first line against high fat [3]. Green coffee bean is promising as an energy supplement which has chlorogenic acid active ingredient which is well known to reduce the cholesterol and triglyceride levels in serum [9]. The residual coffee biomasses studied are able to improve the regeneration of damaged skin tissue, allowing new product development in the cosmetic and pharmaceutical industries [12]
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