In vivo anti-hyperglycemic and antioxidant potentials of ethanolic extract from Tecomella undulata.

Suresh Kumar,Sunil Sharma,Neeru Vasudeva,Varun Ranga

doi:10.1186/1758-5996-4-33

Abstract

This study was undergone to evaluate the in-vivo anti-hyperglycemic and antioxidant potential of ethanolic extract of leaves of Tecomella undulata Seem. on streptozotocin-nicotinamide induced type 2 diabetic rats. Type 2 diabetes was induced by single intraperitoneal injection (i.p.) of 60 mg/kg streptozotocin, 15 minutes after the i.p administration of 110 mg/kg body weight of nicotinamide. The extract has shown significant blood glucose lowering effect in the oral glucose tolerance test (OGTT). The blood glucose level, cholesterol, glycogen contents, glycosylated hemoglobin, and antioxidant parameters (Malondialdehyde and Glutathione level) were estimated from the blood plasma by using standard kits to demonstrate the hypoglycemic and antioxidant effect in treated animals. The data showed that the extract have significant influence on the above biochemical parameters. Thus ethanolic fraction of the plant Tecomella undulata can be used as new candidate for antihyperglycemic and antioxidant.

Highlights

Diabetes mellitus is a common disorder of carbohydrate, fat, and protein metabolism in which the circulating glucose concentration is increased and it causes complications such as retinopathy, microangiopathy, neuropathy and nephropathy [1]
Acute hypoglycemic effect of Tecomella undulata on STZ induced diabetic rats In the acute study of Tecomella undulata 200 mg/kg b. wt p.o. to STZ diabetic rats showed a fall in plasma glucose level from 385 mg/dl to 346 mg/dl at 4th hour when compared to 0 days value
The present study was conducted to access the antihyperglycemic and antioxidant activity of Tecomella undulata leaves extract on STZ induced diabetic rats

Summary

Introduction

Diabetes mellitus is a common disorder of carbohydrate, fat, and protein metabolism in which the circulating glucose concentration is increased and it causes complications such as retinopathy, microangiopathy, neuropathy and nephropathy [1]. This is a chronic incurable condition due to insulin deficiency or lesser action or both that affect 10% of the population [2]. Diabetes affects 150 million people worldwide and this is likely to increase to 300 million by the year 2025 [3]. It has been estimated that diabetic patients in India are expected to increase 57.2 million by the year 2025 [4]. There are increase interest in herbal agents as therapeutic treatment due to their limited adverse effects [5,6,7]

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