Abstract
The metabolism of furaltadone was examined by an in vitro hepatic study in cows and goats and an in vivo study in goats using 14C-labeled and unlabeled drug. The half-life of furaltadone was 13min in the homogenates of caprine and bovine liver and 35min in the in vivo study of the goat. Less than 2% of the parent drug was present in the urine of animals dosed either intravenously or intramammarily. No furaltadone was detected in the milk after 24h. Overall, the parent compound was rapidly absorbed, distributed, and widely degraded in the lactacting goat. The compound, labeled at the 2-formyl carbon of the furan ring, had a radioactivity recovery of 81% in the feces and urine. Of the total radioactivity, 99.4% infused into the udder had been absorbed after 72h. Tissue distributions of radioactivity in decreasing order of abundance were: kidney, udder, liver, duodenum, muscular tissue, adipose tissue, and bile.
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