Abstract
In our search for effective chemotherapy of alveolar hydatid disease we are investigating key enzymes of Echinococcus multilocularis metacestodes. Isatin (2,3-indolinedione) is well known as an inhibitor of alkaline phosphatase activity, and has been previously investigated. Acetylcarboxanilide, an ‘open drug’ of isatin and 2 methacrylanilides were evaluated for their ability to inhibit alkaline phosphatase activity of Echinococcus multilocularis metacestodes in vivo. These ‘open drugs’ are more efficient than isatin, and para-chloromethacrylanilide exhibits a strong selectivity for the parasite enzyme and is also effective in vitro. The results obtained with para-chloromethacrylanilide are promising.
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