Abstract
The effects of bromelain were examined in rats with subcutaneous carrageenin-induced inflammation. After oral in vivo administration, bromelain (10 and 20 mg/kg p.o.) induced a significant decrease of both PGE<sub>2</sub> and substance P concentrations in the exudate. When added to the inflammatory exudate in vitro, the drug (25, 50, 100 µg/ml) did not affect PGE<sub>2</sub> concentrations and induced an increase in the substance P levels. Our data indicate that bromelain reduces the production of two key mediators of inflammation. This effect does not seem to be related to a direct action of the drug on PGE<sub>2</sub> and SP released in the exudate in response to the inflammatory stimulus.
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