Abstract
The activity of garlic oil extract against Schistosoma japonicum cercariae was evaluated. The in vitro and in vivo cercaricidal activities against S. japonicum larvae were determined. Exposure to ≥ 10-6 (v/v) garlic emulsions for 30 min led to 100% cercariae mortality; pre-exposure treatment with ≥ 10-4 (v/v) garlic emulsions showed 100% preventive efficacy against S. japonicum infection, while pre-treatment with 10-5 and 10-6 (v/v) emulsions achieved 20%-40% preventive efficacy and 35.2%-63.6% worm burden reduction. Garlic oil extract has activity against S. japonicum larvae and a promising preventive efficacy against S. japonicum infection.
Highlights
The activity of garlic oil extract against Schistosoma japonicum cercariae was evaluated
Laboratory experiments have shown the promising activity of some plant-derived agents against S. japonicum cercariae[10,11]; there are currently no commercial plant-derived cercaricides available in China
To evaluate the toxicity of garlic oil extract against S. japonicum, the mice were pre-treated with garlic emulsion on the shaved abdomen, followed by an S. japonicum cercariae challenge[14]
Summary
The activity of garlic oil extract against Schistosoma japonicum cercariae was evaluated. The mice were challenged by applying S. japonicum cercariae to their abdomens for 30 min at 40 ± 1 cercariae/mouse, and they were caged and bred in the Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, People’s Republic of China (Wuxi, China).
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