Abstract
A study was made of the molecular structure and properties of theDrosophila melanogaster enhancer of yellow 1 (e(y)1) gene which is involved in long-range promoter-enhancer interactions. The gene codes for transcription factor TAFII40 (a component of the pre-initiation transcription complex TFIID) and is expressed in all cells at all developmental stages. The protein occurs in virtually all discs of polytene chromosomes. Thee(y)1 gene is maternal, and its product is accumulated in oocytes. Suppression ofe(y)1 is lethal. Two mutations obtained,e(y)1 u1 ande(y)1 P1, result from insertion of Stalker and theP element, respectively. Genetic analysis ofe(y)1 u1 suggests that internal promoters are sensitive to a decrease in TAFII40.
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