Abstract
Objectives: The analgesic, anti-inflammatory and thrombolytic potential of Daemonorops robusta Warb, a Bangladeshi tribal medicinal plant was studied for the first time. So our aim was to evaluate analgesic, anti-inflammatory and thrombolytic activities of fruit extract of D. robusta. Methods: Fresh fruits of plant were extracted with methanol and then subjected to preliminary phytochemical screening. Analgesic activity of the extract was performed against acetic acid induced writhing, hot plate and formalin induced test. Anti-inflammatory effect was evaluated using carrageenan induced paw edema in mice. An in vitro thrombolytic model was used to check the clot lysis potential of the extract. Results: Phytochemical screening showed the presence of alkaloid, carbohydrate, flavonoids, steroid, phlobatanin and saponin. The extract exhibited significant analgesic effect (P
Highlights
Pain as a type of Inflammation is suffered by almost everyone will probably throughout their lifetime (Kennedy, 2007)
It is really assume that eicosanoids created by COX-1 get involved in physiologic functions for instance secretion of mucosa, haemostasis and repair of renal function, while those made by COX-2 contributes to inflammatory other pathological changes (Hinz and Brune, 2002; Kulkarni et al, 2000)
Acute toxicity test The present study demonstrated that oral administration of the methanolic extract of Daemonorops robusta Warb (MEDR) at the various doses did not show any mortality, behavioral changes or allergic manifestations during the 8 hours observation period after administration
Summary
Pain as a type of Inflammation is suffered by almost everyone will probably throughout their lifetime (Kennedy, 2007). Nasir Uddin et al / Journal of Applied Pharmaceutical Science 7 (01); 2017: 104-113 While both isoform catalyze the same reactions, COX-1 is usually a constitutive enzyme in most cells-its activity is just not changed once the cell is grown. Non-steroidal antiinflammatory drugs (NSAIDs) produce their therapeutic effects through inhibition of COX, the enzyme which enables prostaglandins. Non selective inhibition of COX iso-enzyme leads to not just beneficial therapeutic effects but in addition many detrimental effects. Beneficial effects are due to inhibition of COX-2 and detrimental effects result from inhibition of physiological COX-1 (Hinz and Brune, 2000; Urban, 2000a). Two medications that predominantly inhibit only COX-2, rofecoxib and celecoxib, are available by prescription from the United State, India and Bangladesh (Everts et al, 2000; Hinz and Brune, 1999). Natural products, including medicinal plants, have been the key source for obtaining new drugs with therapeutic potential throughout history
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