Abstract
1. Adaptation of β-adrenergic receptors (β-AR) and adenylate cyclase (AC) in rat parotid glands during short-term heat exposure (33°C) were studied. 2. Heat exposure reduced AC activity in response to isoproterenol (IPR). 3. The number of β-AR on the cell surface significantly increased after 24 hr but returned to control level after 48 hr. 4. IPR-induced [ 3H]GDP release was significantly reduced throughout exposure. 5. The data suggest that the major factor which results in the desensitization of AC during short-term heat exposure is a blunted coupling between β-AR and GTP binding protein(s).
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