Abstract
The regulation by α- and β-adrenergic agonists of pineal N-acetyltransferase (NAT) and type II thyroxine 5′-deiodinase (5′-D) in rats at either 2 or 6 weeks of age was studied. The pattern of stimulation was different because NAT activity could be clearly activated by an α-adrenergic agonist, phenylephrine, only in 2-week-old rats. However, isoproterenol, a β-adrenergic agonist, was able to stimulate NAT activity in rats at both 2 and 6 weeks of life. On the other hand, phenylephrine was always ineffective in stimulating 5′-D activity, while isoproterenol clearly activated it at both ages. These results strongly suggest a role for α-adrenergic receptors, in addition to β-adrenergic receptors, in regulating rat pineal NAT activity during development.
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