In VitroEvaluation of Antifungal Activities by Permeation of Ru(III) Complexes Derived from Chitosan-Schiff Base Ligand

Abstract

Background:The transition metal complexes are derived from a natural biopolymer which is a very potent material in various research areas of study.Objective:This study aims to show the preparation of ruthenium(III) complexes from chitosan Schiff base ligand for effective application in antifungal studies.Methods:Chemical modification was carried out through a condensation reaction of chitosan with some aromatic aldehydes, which resulted in the formation of a bidentate Schiff base ligand. The Ru(III) complexes were prepared by complexation of ruthenium metal ion with bidentate ligands. The series of Ru(III) complexes were characterized by Scanning Electron Microscope with Electron dispersive X-ray (SEM-EDX) analysis, Powder XRD. The biopolymer-based transition metal complexes have potential uses for their biological activities. The synthesized metal complexes were directed for antifungal study by the disc diffusion method.Results:The antifungal study results showed that the transition metal complexes have significant antifungal activities against some vital fungal pathogens such as Aspergillus flavus, Aspergillus niger, Fusarium oxysporum, Penicillim chryogenum and Trigoderma veride.Conclusion:A chitosan biopolymer offers some peculiar features such as biodegradability, biocompatibility etc., which are favorable for green synthesis of transition metal complexes through complexation with bidentate ligands. These metal complexes possess good antifungal property due to their chelation effect on micro-organisms.