Abstract
AbstractThe application of a polymer film coat is a common practice in the preparation of controlled release dosage forms. In vitro characterization of the polymeric membrane is essential for optimization of the membrane formulation. Polymers selected in this study were cellulose acetate (CA), ethylcellulose (EC) and copolymers of acrylic and methacrylic esters (Eudragit RL100). Plasticizers used in this study were dibutyl sebacate (DBS), triethyl citrate (TEC) and triacetin. Polymer dispersions containing different plasticizers were cast into membranes on a tefloncoated plate. The resulting membranes were evaluated for permeability and mechanical properties. Membrane permeability was determined by quantifying the transport of a model drug, theophylline, across a circular polymeric membrane mounted in a thermostatted, twocompartment horizontal diffusion cell. Mechanical properties of the membranes, such as tensile strength, percent elongation and modulus of elasticity, were determined using an Instron 430...
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