Abstract
To evaluate the effectiveness of the immunoglobulin (IG) treatment for the prevention of cytomegalovirus (CMV) pneumonia in the cases with allogenic bone marrow transplantation (BMT), we examined the neutralizing activity of the IG preparation against both the free CMV particles and the cells infected with CMV in vitro. The results were as follows: 1) IG neutralized the free CMV particles but not the cells infected with CMV. 2) There was no difference in the number and size of plaques between the two overlay media with and without IG. These findings suggest that IG can not obstruct the cell to cell infection with CMV. Accordingly, it is concluded that if the effect of IG treatment in BMT cases is originated from the neutralizing antibody, it may be explained by neutralizing of the free viruses but not by obstructing the cell to cell infection with CMV.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of the Japanese Association for Infectious Diseases
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
