Abstract
Both normal and diseased human prostatic tissue have a demonstrable affinity for zine, and evidence is presented that this affinity is due to acidic substances within the prostatic tissue, notably sulfated acid mucopolysaccharides. Additionally, there appears to be an inverse relationship between the in vivo concentration of zinc and in vitro zinc-binding capacity in cancerous and hyperplastic tissues. The higher the concentration of zine found in vivo, the less is the affinity of such tissue for zinc in vitro. It is possible that the low in vitro uptake of zinc in hyperplastic tissues is an expression of the in vivo saturation of zinc-binding sites, whereas the high in vitro uptake of zinc by carcinomatous prostatic tissue is an indication that these sites in vivo may not be readily accessible to zinc.
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