Abstract
Interest concerning the possible adverse effects of cosmetic products is increasing and at the same time toxicologists are faced with the problems arising from in vivo testing and the growing development of alternative methods. A series of n-alkyl benzoates has been tested on a continuous cell line (HEp-2). Dose-effect correlations have been established for methyl, ethyl, n-propyl and n-butyl benzoates by determining the total protein content of the cells at 24 hr. The toxicity ranking of these benzoates according to the IC 50 has been shown to be butyl > propyl > ethyl > methyl benzoate. Experiments carried out on time-effect correlation and on colony-forming ability seem to suggest that the damage does not increase with time and is probably caused mostly by an initial selective effect on the cell population.
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