Abstract
Hagfish ( Eptatretus stouti) thyroid tissue was maintained in organ culture with hagfish pituitary or bovine thyroid-stimulating hormone (b-TSH). Possible thyrotropic effects of pituitary co-culture or b-TSH were assessed by radioimmunoassay of the thyroxine (T 4) concentration in culture medium. Thyroid tissue co-cultured with hagfish pituitary released a greater amount (20–100%) of T 4 into the medium than thyroid tissue cultured alone or with connective tissue (control). Addition of bovine thyrotropic hormone at two different doses (25 ng/ml and 25 μg/ml) resulted in a slight but statistically nonsignificant increase in T 4 levels. Stimulation of T 4 release during pituitary co-culture indicates the existence of a thyrotropic factor in the hagfish adenohypophysis.
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