Abstract
Enterococci with gentamicin MICs of 256 to 1,024 μg/mL were evaluated for susceptibility to ampicillin plus gentamicin synergism. Sixteen of eighteen enterococcal isolates were not susceptible to synergistic killing by ampicillin plus gentamicin; 11 possessed aac(6′)-aph(2″), and 4 possessed aph(2″)-Ic. A gentamicin MIC of 512 or 1,024 μg/mL predicted lack of ampicillin/gentamicin synergism, but a gentamicin MIC of 256 μg/mL did not. For six enterococcal strains possessing the gentamicin-resistance gene aph(2″)-Ic, ampicillin plus dibekacin, ampicillin plus netilmicin, and ampicillin plus amikacin produced synergistic killing in five, three, and two strains, respectively.
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