Abstract

Objective To investigate the binding characteristics of ~(18)F-fluorodeoxyglucose(~(18)F-FDG)and ~(18)F-fluorodeoxythymidine(~(18)F-FLT)with human lymphoma cell Raji and the differences between them.Methods The binding rates of ~(18)F-FDG and ~(18)F-FLT was measured under different conditions:1×10~5～1×10~7cells.1.85～29.6kBq ~(18)F-FDG or ~(18)F-FLT,0～11.1mmol/L glucose levels and 20～120 min to measure.Results The binding rate of ~(18)F-FDG waa(50.42±1.07)%at the condition of 1×10~7 cells,3.7kBq ~(18)F-FDG,0～2.78mmol/L glucose levels.100min.while ~(18)F-FLT was(59.48±0.77)%at the same conditions.The difiefence of binding rates between~(18)F-FDG and ~(18)F-FLT was significant(F=1192.805,P<0.001).Conclusion The uptake of ~(18)F-FDG and ~(18)F-FLT in human lymphoma Raji cell is high,and at the same condition,the uptake rate of ~(18)F-FLT is higher than ~(18)F-FDG. Key words: Lymphoma; Fluorodeoxyglucose; Thymine nucleotides; Cell conjugation rate

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