In Vitro Study of Temperature and pH-Responsive Gentamycin Sulphate-Loaded Chitosan-Based Hydrogel Films for Wound Dressing Applications

Abstract

Developments in the field of polymer science have led us to the development of Chitosan and PNIPAm mixed pH and temperature responsive hydrogel films. Characterizations were done by Swelling analysis, FTIR, DSC, FESEM and Antibacterial assay. Optimized hydrogel film on swelling analysis does not lose its shape and was not dissolve in to the different buffer solution and at different temperature. FTIR, DSC and FESEM study confirmed the changes in to the hydrogel film after drug absorption. On increasing the temperature and change in pH of the solution, drug absorption increased which was confirmed by zone of inhibition against E. coli.