In vitro study of magnetic particle seeding for implant-assisted-magnetic drug targeting: Seed and magnetic drug carrier particle capture

Abstract

An implant-assisted-magnetic drug targeting system using seed particles as the implant to increase the capture of magnetic drug carrier particles (MDCPs) in capillary tissue was studied in vitro. Dextran-coated magnetite particles were used as seeds, polydivinylbenzene magnetite particles were used as MDCPs, and a polyethylene porous cylinder was used as surrogate capillary tissue. The results showed that seeds could be magnetically captured first and then used to magnetically capture the MDCPs, causing a significant increase in their collection compared to when the seeds were absent.