Abstract
Background: Diabetes mellitus, a heterogeneous metabolic disease characterized by altered carbohydrate, protein and lipid metabolism. Increased glucose level has a causal correlation with atherosclerotic changes in diabetic patients. Regulating blood glucose may prevent diabetes-related tissue damage and secondary complications associated.
 Methods: In the present study, an attempt has been made to investigate the Anti-diabetic and Anti-atherosclerotic effect exhibited by Cold and Hot extracts of Trigonella foenum leaves samples.
 Results: It was deduced that the Cold extracts of fenugreek leaves had more of Phenolic compounds, while the Hot extracts had Increased amount of Carbohydrates. In the Anti Atherosclerotic studies, it was observed that the Cold extract (34%) possessed higher Cardioprotective activity than the Hot extract (14%) of T. foenum leaves when compared with the Ascorbic acid (80%) as Standard. Increased glucose level has a causal correlation with atherosclerotic changes in diabetic patients. The Antidiabetic studies of both the extracts Hot and Cold of T. foenum leaves were studied. In the Alpha- amylase inhibition assay, it was seen that both the Cold (70.1±3.5) and Hot extract (69.1±2.5) of T. foenum leaves showed significant results when compared with the Standard Acorbase (72.5±2.0). Similarly, in Glucose diffusion inhibition assay, it was seen that both the Cold (48.54%) and Hot extract (47.51%) of T. foenum leaves, when compared with the standard Metformin (70.84%) showed potent Anti-Diabetic activity.
 Conclusion: From the above results, it can be concluded that T. foenum leaves in both Hot and Cold treated, possesses antioxidant activity, anti-atherosclerotic, anti-diabetic activity.
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