Abstract
“Nonsensitive” cells from skin-test-negative individuals were incubated with whole cell lysates, nondialyzable and dialyzable fractions of leucocyte lysates obtained from strongly skin test sensitive histoplasmin, and/or coccidioidin sensitive donors and specific antigen. “Nonsensitive” cells incubated with whole cell lysate or nondialyzable fractions of lysate in the presence of specific antigen released a substance (MIF) which specifically inhibited the migration of guinea pig macrophages. Dialyzable fractions from active cell lysates incubated with “nonsensitive” cells and specific antigen did not liberate MIF from “nonsensitive” cells. Cell lysates, nondialyzable fractions, or dialyzable fractions alone, or in combination with nonspecific antigens in the presence of “nonsensitive” cells failed to inhibit the migration of guinea pig macrophages.
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