Abstract
In vitro Studies of the Antibody Response: Antibodies of Different Specificity are Made in Different Populations of Cells.
Highlights
Our paper [1] “Cell populations and cell proliferation in the in vitro response of normal mouse spleen to heterologous erythrocytes
Analysis by the hot pulse technique,” investigated the kinetics of antigen driven proliferation of antibody forming cells in culture and showed that different populations of cells were involved in the response to two different antigens, providing evidence for the clonal selection theory proposed by both Sir McFarlane Burnet and by David Talmage
I was trained as a biochemist in England but switched to immunology when I was given the opportunity to come to the United States to join John Vaughan’s lab at the Medical College of Virginia in Richmond, Virginia
Summary
Our paper [1] “Cell populations and cell proliferation in the in vitro response of normal mouse spleen to heterologous erythrocytes. Analysis by the hot pulse technique,” investigated the kinetics of antigen driven proliferation of antibody forming cells in culture and showed that different populations of cells were involved in the response to two different antigens, providing evidence for the clonal selection theory proposed by both Sir McFarlane Burnet and by David Talmage.
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