Abstract
In order to improve blood compatibility, the surfaces of polyethylene terephthalate (PET) were treated using CO2 pulsed and KrF excimer lasers. The physico-chemical characterization of the laser-treated PET surfaces was carried out through attenuated total reflectance infrared spectroscopy and contact-angle measurements. The hemocompatibility of the laser-irradiated PET films was examined in vitro to evaluate their capability of inducing platelet adhesion in comparison with unmodified PET. The number of adhered platelets was determined by lactate dehydrogenase (LDH) activity measurement. Platelet adhesion on the untreated PET was relatively high compared to the laser-treated samples. Laser irradiation of PET surface reduced the number of adherent platelets and prevented platelet spreading on the surface. Reduction of platelet adhesion was attributed to the change in morphology, chemical structure, and crystallinity of the PET surface due to laser irradiation with various numbers of pulses. The morphology of adhered platelets on the PET surfaces was investigated by scanning electron microscopy (SEM). The SEM observations were consistent with the results obtained from LDH activity measurement. © 2000 John Wiley & Sons, Inc. J Biomed Mater 54: 540–546, 2001
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
