In vitro studies of B2O3–SiO2–Na2O–CaO–ZnO bioactive glass system

Abstract

The main purpose of the present investigation is to examine in detail in vitro studies like bioactivity and cytocompatibility of a novel bioactive glass system i.e., B2O3–SiO2–Na2O–CaO–ZnO glass composition. Glasses are prepared by the traditional melt quenching method. In vitro studies are performed with ISO standards. Bioactivity has been studied using standard Kokubo's method. Highly sophisticated analytical techniques were utilized for the assessment of apatite forming ability. Scanning electron microscopy micrographs have shown visible evidence of apatite forming ability through cauliflower type of precipitation on the surface of the glass. Cytocompatibility was performed using human osteoblast cells (MG-63). Cytocompatibility of zinc-containing soda lime borosilicate glasses has shown significant results for bone tissue engineering applications.