Abstract
Despite recent advances in the field of chemically synthesized pharmaceutical agents, nature remains the primary source of bioactive molecules. Natural product research is a valuable approach for the discovery and development of novel biologically active compounds with unique structures and mechanisms of action. Despite their use in traditional treatment regimes, plant-derived compounds still account for a significant portion of today's pharmaceutical agents. Their medical significance is widely acknowledged in the field of oncology, particularly as an alternative to the limitations of conventional chemotherapy (severe side effects and inefficacy due to the occurrence of multi-drug resistance). Furthermore, the preclinical to clinical evaluation of the most recently studied natural compounds with potent antitumor activity (e.g., resveratrol, curcumin, betulinic acid, etc.) in terms of anticancer mechanisms of action and potential indications as chemotherapeutic or chemopreventive agents and sensitizers is depicted. Finally, this review describes several effective platforms for the encapsulation and targeted delivery of natural compounds in cancer treatment. This review uses representation to provide a comprehensive view of the mechanism of action of the agents of natural origin.
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