Abstract
Human monocytes isolated from peripheral blood can be stimulated in vitro to produce a procoagulant which is very similar or identical to tissue thromboplastin. Immune complexes formed by transferrin/antitransferrin and albumin/antialbumin at equivalence induce a marked increase in this thromboplastic activity. Lectins (phytohaemagglutinin, wheat germ agglutinin and concanavalin A) have a similar effect. The specific thromboplastin activity of homogenates of stimulated monocytes reaches levels equivalent to or higher than those of ordinary crude brain thromboplastin preparations. The induction of this activity in monocytes by immune complexes and other endogenous stimulants may be of clinical significance.
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