Abstract
Purpose: Gelatin methacrylol (GelMA) hydrogels are widely used for cartilage regeneration. There are many types of GelMAs and gelatins commercially available, but their exact endotoxin content is often not stated. Endotoxins and other pro-inflammatory factors are known to influence cartilage health and repair. Unravelling the impact of such endotoxin content can help understand if these materials are suitable for regenerative purposes. It also poses the question whether in vitro Results obtained with endotoxin containing hydrogels can be translated to the clinic.
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