In Vitro Release of Cisplatin from Sol-Gel Processed Porous Silica Xerogels

Abstract

Cisplatin an antineoplastic medicine, was incorporated into a silica gel received by the sol-gel method. Various techniques of trapping an active substance in gel were applied: at the stage of sol creation—by the predoping method—and already upon receipt of hard xerogel—the postdoping method. Further, the research aimed at the determination of the dynamics of cisplatin release from sol-gel processed silica xerogel to the water phase. Based on the achieved results, we may state that the sol-gel method is useful for trapping a medicine like cisplatin in silica gel and gives repeatable results with regard to medicine release from the pores of the so-established matrix. The postdoping method appeared to be more beneficial, because the gained gel's active substance is released almost entirely (94–96%). The time of release was 3 days.